Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates.
نویسندگان
چکیده
Chlamydia psittaci produces a collection of proteins, termed IncA, IncB, and IncC, that are localized to the chlamydial inclusion membrane. In this report we demonstrate that IncA is also produced by Chlamydia trachomatis. C. trachomatis IncA is structurally similar to C. psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA.
منابع مشابه
Conservation of the biochemical properties of IncA from Chlamydia trachomatis and Chlamydia caviae: oligomerization of IncA mediates interaction between facing membranes.
The developmental cycle of Chlamydiaceae occurs in a membrane compartment called an inclusion. IncA is a member of a family of proteins synthesized and secreted onto the inclusion membrane by bacteria. IncA proteins from different species of Chlamydiaceae show little sequence similarity. We report that the biochemical properties of Chlamydia trachomatis and Chlamydia caviae are conserved. Both ...
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متن کاملConservation of the biochemical properties of IncA from Chlamydia trachomatis and C. caviae : oligomerization of IncA mediates interaction between facing membranes
The developmental cycle of Chlamydiaceae occurs in a membrane compartment called an inclusion. IncA is a member of a family of proteins synthesized and secreted onto the inclusion membrane by the bacteria. IncA proteins from different species of Chlamydiaceae show little sequence similarity. We report that the biochemical properties of C. trachomatis and C. caviae are conserved. Both proteins a...
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Chlamydia trachomatis replicates in a parasitophorous membrane-bound compartment called an inclusion. The inclusions corrupt host vesicle trafficking networks to avoid the degradative endolysosomal pathway but promote fusion with each other in order to sustain higher bacterial loads in a process known as homotypic fusion. The Chlamydia protein IncA (Inclusion protein A) appears to play central ...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 66 12 شماره
صفحات -
تاریخ انتشار 1998